Article

GSK3 inhibition reverts mesenchymal transition in human primary corneal endothelial cells

2022-11-25

Abstract excerpt

Human corneal endothelial cells are organized in a tight mosaic of hexagonal cells and serve a critical function in maintaining corneal hydration and clear vision. Regeneration of the corneal endothelial tissue is hampered by its poor proliferative capacity, which is partially retrieved in vitro , albeit only for a limited number of passages before the cells undergo mesenchymal transition (EnMT). Although differe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0efc630e-9666-5596-9837-800651e3e7f2
DOI: 10.1101/2022.11.25.517972

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GSK3 inhibition reverts mesenchymal transition in human primary corneal endothelial cellsDOI 10.1101/2022.11.25.517972Read

GSK-3 inhibition reverts mesenchymal transition in primary human corneal endothelial cellsSemantic proximity Read

In Vitro Expansion of Corneal Endothelial Cells for Clinical Application: Current UpdateSemantic proximity Read

Inhibition of TGF-β signaling enables human corneal endothelial cell expansion in vitro for use in regenerative medicine.Semantic proximity Read

An efficient simplified method for the generation of corneal epithelial cells from human pluripotent stem cellsSemantic proximity Read

Telomerase Immortalization of Human Corneal Endothelial Cells Yields Functional Hexagonal MonolayersSemantic proximity Read

IGFBP4 suppresses EndMT and preserves rabbit corneal endothelial cell phenotypes by inhibiting the Wnt2/β-catenin signaling pathway.Semantic proximity Read

Effect of porcine corneal stromal extract on keratocytes from SMILE-derived lenticules.Semantic proximity Read

A single-cell RNA-seq analysis unravels the heterogeneity of primary cultured human corneal endothelial cellsSemantic proximity Read

A Single-Cell RNA-Seq Analysis Unravels the Heterogeniety of Primary Cultured Human Corneal Endothelial CellsSemantic proximity Read

Directed Differentiation of Human Pluripotent Stem Cells towards Corneal Endothelial-Like Cells under Defined ConditionsSemantic proximity Read

Long-term Observation After Transplantation of Cultured Human Corneal Endothelial Cells for Corneal Endothelial DysfunctionSemantic proximity Read

Feeder-free differentiation of cells exhibiting characteristics of corneal endothelium from human induced pluripotent stem cellsSemantic proximity Read