Article
Genome-wide association analysis identifies new candidate risk loci for familial intracranial aneurysm in the French-Canadian population.
Scientific reports - 12 Mar 2018
Zhou Sirui, Gan-Or Ziv, Ambalavanan Amirthagowri, Lai Dongbing, Xie Pingxing, Bourassa Cynthia V, Strong Stephanie, Ross Jay P, Dionne-Laporte Alexandre, Spiegelman Dan, Dupré Nicolas, Foroud Tatiana M, Xiong Lan, Dion Patrick A, Rouleau Guy A
Abstract excerpt
Intracranial Aneurysm (IA) is a common disease with a worldwide prevalence of 1-3%. In the French-Canadian (FC) population, where there is an important founder effect, the incidence of IA is higher and is frequently seen in families. In this study, we genotyped a cohort of 257 mostly familial FC IA patients and 1,992 FC controls using the Illumina NeuroX SNP-chip. The most strongly associated loci were tested in...
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