Article
RNF213 Is Associated with Intracranial Aneurysms in the French-Canadian Population.
American journal of human genetics - 3 Nov 2016
Zhou Sirui, Ambalavanan Amirthagowri, Rochefort Daniel, Xie Pingxing, Bourassa Cynthia V, Hince Pascale, Dionne-Laporte Alexandre, Spiegelman Dan, Gan-Or Ziv, Mirarchi Cathy, Zaharieva Vessela, Dupré Nicolas, Kobayashi Hatasu, Hitomi Toshiaki, Harada Kouji, Koizumi Akio, Xiong Lan, Dion Patrick A, Rouleau Guy A
Abstract excerpt
Intracranial aneurysms (IAs) are the result of focal weakness in the artery wall and have a complex genetic makeup. To date, genome-wide association and sequencing studies have had limited success in identifying IA risk factors. Distinct populations, such as the French-Canadian (FC) population, have increased IA prevalence. In our study, we used exome sequencing to prioritize risk variants in a discovery cohort...
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