Article
Capture Hi-C identifies putative target genes at 33 breast cancer risk loci.
Nature communications - 12 Mar 2018
Baxter Joseph S, Leavy Olivia C, Dryden Nicola H, Maguire Sarah, Johnson Nichola, Fedele Vita, Simigdala Nikiana, Martin Lesley-Ann, Andrews Simon, Wingett Steven W, Assiotis Ioannis, Fenwick Kerry, Chauhan Ritika, Rust Alistair G, Orr Nick, Dudbridge Frank, Haider Syed, Fletcher Olivia
Abstract excerpt
Genome-wide association studies (GWAS) have identified approximately 100 breast cancer risk loci. Translating these findings into a greater understanding of the mechanisms that influence disease risk requires identification of the genes or non-coding RNAs that mediate these associations. Here, we use Capture Hi-C (CHi-C) to annotate 63 loci; we identify 110 putative target genes at 33 loci. To assess the support...
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