Article
Combined prediction and design reveals the target recognition mechanism of an intrinsically disordered protein interaction domain.
Proceedings of the National Academy of Sciences of the United States of America - 26 Sept 2023
Hu Xiuhong, Xu Yang, Wang Chenchen, Liu Yufeng, Zhang Lu, Zhang Jiahai, Wang Wenning, Chen Quan, Liu Haiyan
Abstract excerpt
An increasing number of protein interaction domains and their targets are being found to be intrinsically disordered proteins (IDPs). The corresponding target recognition mechanisms are mostly elusive because of challenges in performing detailed structural analysis of highly dynamic IDP-IDP complexes. Here, we show that by combining recently developed computational approaches with experiments, the structure of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.