Article
Canonical and Noncanonical Sites Determine NPT2A Binding Selectivity to NHERF1 PDZ1.
PloS one - 1 Jan 2015
Mamonova Tatyana, Zhang Qiangmin, Khajeh Jahan Ali, Bu Zimei, Bisello Alessandro, Friedman Peter A
Abstract excerpt
Na+/H+ Exchanger Regulatory Factor-1 (NHERF1) is a scaffolding protein containing 2 PDZ domains that coordinates the assembly and trafficking of transmembrane receptors and ion channels. Most target proteins harboring a C-terminus recognition motif bind more-or-less equivalently to the either PDZ domain, which contain identical core-binding motifs. However some substrates such as the type II sodium-dependent...
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