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Article

Cooperation among heterogeneous prostate cancer cells in the bone metastatic niche.

Oncogene - 18 May 2017

Shahriari K, Shen F, Worrede-Mahdi A, Liu Q, Gong Y, Garcia F U, Fatatis A

Abstract excerpt

The growth of disseminated tumor cells into metastatic lesions depends on the establishment of a favorable microenvironment in the stroma of the target organs. Here we show that mice treated with anakinra, an antagonist of the interleukin (IL)-1β receptor (IL-1R), or harboring a targeted deletion of IL-1R are significantly less prone to develop bone tumors when inoculated in the arterial circulation with human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27991924
DOI: 10.1038/onc.2016.436
PMCID: PMC5436952

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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