Article

RELA is Sufficient to Mediate Interleukin-1 (IL-1) Repression of Androgen Receptor Expression and Activity in LNCaP Disease Progression Model

2019-09-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The Androgen Receptor (AR) nuclear transcription factor is a therapeutic target for prostate cancer (PCa). Unfortunately, patients can develop resistance to AR-targeted therapies and progress to lethal disease, underscoring the importance of understanding the molecular mechanisms that underlie treatment resistance. Inflammation is implicated in PCa initiation and progression...

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Literature Corpus work: 93301ac3-0828-5a35-b1d2-c82070ce475b
DOI: 10.1101/775320

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