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Mitochondrial sulfide promotes life span and health span through distinct mechanisms in developing versus adult treated Caenorhabditis elegans

31 Jul 2023

Abstract excerpt

Living longer without simultaneously extending years spent in good health (“health span”) is an increasing societal burden, demanding new therapeutic strategies. Hydrogen sulfide (H 2 S) can correct disease-related mitochondrial metabolic deficiencies, and supraphysiological H 2 S concentrations can pro health span. However, the efficacy and mechanisms of mitochondrion-targeted sulfide delivery molecules (mtH 2...

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PMID: 37523525
DOI: 10.1073/pnas.2216141120

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