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The potential effect and pathway of valsartan: genome-wide and phenome-wide association study from UK Biobank data.

Pharmacogenetics and genomics - 1 Jul 2026

Zeng Shengyin, Li Yaxin, Zhang Yucong, Lu Yueqi, Ruan Lei, Zhang Cuntai, Zhang Jianguo, Chen Bangwei, Li Tao

Abstract excerpt

PURPOSE: Valsartan, an angiotensin II receptor blocker, is widely used for hypertension and heart failure. While its cardiovascular benefits are established, its broader pharmacological effects remain incompletely characterized. This study aimed to identify genetic variants associated with valsartan use and to systematically explore its potential effects and adverse events across a wide range of phenotypes....

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Identifiers

PMID: 41861149
DOI: 10.1097/FPC.0000000000000597
PMCID: PMC13200868

Genes

GCLC
PREP
ZNF133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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