Article
Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles.
PLoS pathogens - 1 Feb 2018
Zhang Ning, Zoltner Martin, Leung Ka-Fai, Scullion Paul, Hutchinson Sebastian, Del Pino Ricardo C, Vincent Isabel M, Zhang Yong-Kang, Freund Yvonne R, Alley Michael R K, Jacobs Robert T, Read Kevin D, Barrett Michael P, Horn David, Field Mark C
Abstract excerpt
Recent development of benzoxaborole-based chemistry gave rise to a collection of compounds with great potential in targeting diverse infectious diseases, including human African Trypanosomiasis (HAT), a devastating neglected tropical disease. However, further medicinal development is largely restricted by a lack of insight into mechanism of action (MoA) in pathogenic kinetoplastids. We adopted a multidisciplinary...
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