Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ionophore A23187 shows anti-tuberculosis activity and synergy with tebipenem.

Tuberculosis (Edinburgh, Scotland) - 1 Dec 2017

Huang Wei, Briffotaux Julien, Wang Xinwei, Liu Lili, Hao Pei, Cimino Mena, Buchieri Maria Virginia, Namouchi Amine, Ainsa Jose-Antonio, Gicquel Brigitte

Abstract excerpt

The objective of this study was to find molecules with anti-mycobacterial activity from a natural compounds library, investigate their mechanisms of resistance, and assess their synergy with antibiotics. We screened a library of 2582 natural compounds with Mycobacterium aurum with the aim of identifying molecules with anti-mycobacterial activity. The hits with the lowest MICs in M. aurum were also tested for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotics, Antitubercular
Share to Calcimycin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carbapenems

Share to Drug Resistance, Bacterial

Share to Drug Synergism

Share to Macrophages

Share to Membrane Transport Proteins

Share to Mycobacterium tuberculosis

Source

Identifiers

PMID: 29050757
DOI: 10.1016/j.tube.2017.09.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ionophore A23187 shows anti-tuberculosis activity and synergy with tebipenem.PMID 29050757Read ↗

Strategies in anti-Mycobacterium tuberculosis drug discovery based on phenotypic screeningSemantic proximity Read ↗

Hit Compounds and Associated Targets in Intracellular Mycobacterium tuberculosis.Semantic proximity Read ↗

Molecular docking, molecular dynamics simulations and binding free energy studies of interactions between Mycobacterium tuberculosis Pks13, PknG and bioactive constituents of extremophilic bacteriaSemantic proximity Read ↗

Naturally occurring Dinactin targets cpsA of LytR-Cps2A-Psr family protein as well as kills Mycobacterium tuberculosis by disrupting proton motive forceSemantic proximity Read ↗

Screening of Compounds for Anti-tuberculosis Activity, and in vitro and in vivo Evaluation of Potential CandidatesSemantic proximity Read ↗

Identification of the anti-mycobacterial functional properties of piperidinol derivatives.Semantic proximity Read ↗

Novel Acetamide Indirectly Targets Mycobacterial Transporter MmpL3 by Proton Motive Force DisruptionSemantic proximity Read ↗

Mycobacterial Membrane Protein Large 3 (MmpL3) Inhibitors: A Promising Approach to Combat TuberculosisSemantic proximity Read ↗

Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targets.Semantic proximity Read ↗

Inhibitors of mycobacterial efflux pumps as potential boosters for anti-tubercular drugsSemantic proximity Read ↗

Pre-clinical evaluation of quinoxaline-derived chalcones in tuberculosis.Semantic proximity Read ↗

Ion Channel Blockers as Antimicrobial Agents, Efflux Inhibitors, and Enhancers of Macrophage Killing Activity against Drug Resistant Mycobacterium tuberculosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.