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Article

Role of Akt Isoforms Controlling Cancer Stem Cell Survival, Phenotype and Self-Renewal

7 Mar 2018

Abstract excerpt

The cancer stem cell (CSC) hypothesis suggests that tumours are maintained by a subpopulation of cells with stem cell properties. Although the existence of CSCs was initially described in human leukaemia, less evidence exists for CSCs in solid tumours. Recently, a CD133+ cell subpopulation was isolated from human brain tumoursexhibiting stem cell properties in vitro as well as the capacity to initiate tumours in...

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PMID: 29518912
DOI: 10.3390/biomedicines6010029

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