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Article

Osteosarcoma-derived extracellular vesicles induce a tumor-like phenotype in normal recipient cells.

Journal of cellular physiology - 1 Aug 2018

Urciuoli Enrica, Giorda Ezio, Scarsella Marco, Petrini Stefania, Peruzzi Barbara

Abstract excerpt

Osteosarcoma is the most common primary bone cancer and the most frequent cause of bone cancer-related deaths in children and adolescents. Osteosarcoma cells are able to establish a crosstalk with resident bone cells leading to the formation of a deleterious vicious cycle. We hypothesized that osteosarcoma cells can release, in the bone microenvironment, transforming Extracellular Vesicles (EVs) involved in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29323709
DOI: 10.1002/jcp.26464

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TNF

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