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Article

The HUS box is required for allosteric regulation of the Sec7 Arf-GEF.

The Journal of biological chemistry - 4 May 2018

Halaby Steve L, Fromme J Christopher

Abstract excerpt

The Golgi complex is the central membrane and protein-sorting station in eukaryotic cells. Activation of Arf (ADP-ribosylation factor) GTPases is essential for vesicle formation via recruitment of cargo adaptors and coat proteins necessary for Golgi trafficking. Arf activation is spatially and temporally regulated by distinct guanine nucleotide exchange factors (GEFs) at different Golgi compartments. The yeast...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29514977
DOI: 10.1074/jbc.RA117.001318
PMCID: PMC5936818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The HUS box is required for allosteric regulation of the Sec7 Arf-GEF.PMID 29514977Read ↗

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