Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1.

doi:10.1038/s41467-018-03433-3

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1.

Nature communications - 6 Mar 2018

Hernández Gonzalo, Ramírez María José, Minguillón Jordi, Quiles Paco, Ruiz de Garibay Gorka, Aza-Carmona Miriam, Bogliolo Massimo, Pujol Roser, Prados-Carvajal Rosario, Fernández Juana, García Nadia, López Adrià, Gutiérrez-Enríquez Sara, Diez Orland, Benítez Javier, Salinas Mónica, Teulé Alex, Brunet Joan, Radice Paolo, Peterlongo Paolo, Schindler Detlev, Huertas Pablo, Puente Xose S, Lázaro Conxi, Pujana Miquel Àngel, Surrallés Jordi

Abstract excerpt

BRCA1 is a tumor suppressor that regulates DNA repair by homologous recombination. Germline mutations in BRCA1 are associated with increased risk of breast and ovarian cancer and BRCA1 deficient tumors are exquisitely sensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. Therefore, uncovering additional components of this DNA repair pathway is of extreme importance for further understanding cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carrier Proteins

Share to DNA Repair

Share to Homologous Recombination

Share to Nuclear Proteins

Share to Poly (ADP-Ribose) Polymerase-1

Share to Proteins

Share to RNA Caps

Source

Open in PubMed Open full text

Identifiers

PMID: 29511213
DOI: 10.1038/s41467-018-03433-3
PMCID: PMC5840268

Genes

BRCA1
BRIP1
TOPBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1.PMID 29511213Read ↗

The EDC4-XRN1 axis controls P-body dynamics to link mRNA decapping with decaySemantic proximity Read ↗

The Human Exonuclease-1 Interactome And Phosphorylation SitesSemantic proximity Read ↗

Elevated DNA Polymerase Delta 1 Expression Correlates With Tumor Progression and Immunosuppressive Tumor Microenvironment in Hepatocellular CarcinomaSemantic proximity Read ↗

Human DCP1 is crucial for mRNA decapping and possesses paralog-specific gene regulating functionsSemantic proximity Read ↗

Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stabilitySemantic proximity Read ↗

LARP7 is a BRCA1 ubiquitinase substrate and regulates genome stability and tumorigenesisSemantic proximity Read ↗

Control of mRNA decapping by positive and negative regulatory elements in the Dcp2 C-terminal domain.Semantic proximity Read ↗

Roles of RNA-Binding Proteins in DNA Damage ResponseSemantic proximity Read ↗

Prolyl Isomerase PIN1 Regulates DNA Double-Strand Break Repair by Counteracting DNA End ResectionSemantic proximity Read ↗

EDC3 phosphorylation regulates growth and invasion through controlling P-body formation and dynamics.Semantic proximity Read ↗

The BRCA1/BARD1 ubiquitin ligase and its substrates.Semantic proximity Read ↗

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCISemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.