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LARP7 is a BRCA1 ubiquitinase substrate and regulates genome stability and tumorigenesis

2019-10-17

Abstract excerpt

<h4>Summary</h4> Attenuated DNA repair leads to genomic instability and tumorigenesis. BRCA1/BARD1 are the best known tumor suppressors that promote homology recombination (HR) and arrest cell cycle at G2/M checkpoint. As E3 ubiquitin ligases, their ubiquitinase activity has been known to involve in the HR and tumor suppression, but the mechanism remains ambiguous. Here, we demonstrated upon genotoxic stress, BRC...

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Literature Corpus work
3dca8350-fb46-51ff-958b-ab1592695c87
DOI
10.1101/808535
Open publication

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