Article
Hsa-miR-31 Governs T-Cell Homeostasis in HIV Protection via IFN-γ-Stat1-T-Bet Axis.
Frontiers in immunology - 1 Jan 2021
Zhu Lingyan, Qiu Chao, Dai Lili, Zhang Linxia, Feng Meiqi, Yang Yu, Qiu Chenli, Zhang Anli, Huang Jun, Wang Ying, Wan Ying, Zhao Chen, Wu Hao, Lyu Jianxin, Zhang Xiaoyan, Xu Jianqing
Abstract excerpt
It remains poorly defined whether any human miRNAs play protective roles during HIV infection. Here, focusing on a unique cohort of HIV-infected former blood donors, we identified miR-31 (hsa-miR-31) by comparative miRNA profiling as the only miRNA inversely correlating with disease progression. We further validated this association in two prospective cohort studies. Despite conservation during evolution,...
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