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Article

Conformational transitions of the sodium-dependent sugar transporter, vSGLT.

Proceedings of the National Academy of Sciences of the United States of America - 20 Mar 2018

Paz Aviv, Claxton Derek P, Kumar Jay Prakash, Kazmier Kelli, Bisignano Paola, Sharma Shruti, Nolte Shannon A, Liwag Terrin M, Nayak Vinod, Wright Ernest M, Grabe Michael, Mchaourab Hassane S, Abramson Jeff

Abstract excerpt

Sodium-dependent transporters couple the flow of Na+ ions down their electrochemical potential gradient to the uphill transport of various ligands. Many of these transporters share a common core structure composed of a five-helix inverted repeat and deliver their cargo utilizing an alternating-access mechanism. A detailed characterization of inward-facing conformations of the Na+-dependent sugar transporter from...

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Identifiers

PMID: 29507231
DOI: 10.1073/pnas.1718451115
PMCID: PMC5866573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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