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Article

Prenatal flutamide enhances survival in a myogenic mouse model of spinal bulbar muscular atrophy.

Neuro-degenerative diseases - 1 Jan 2011

Johansen Jamie A, Troxell-Smith Sandra M, Yu Zhigang, Mo Kaiguo, Monks D Ashley, Lieberman Andrew P, Breedlove S Marc, Jordan Cynthia L

Abstract excerpt

BACKGROUND: Spinal bulbar muscular atrophy (SBMA) is caused by a CAG repeat expansion mutation in the androgen receptor (AR) gene, and mutant AR is presumed to act in motoneurons to cause SBMA. However, we found that mice overexpressing wild-type (wt) AR solely in skeletal muscle fibers display the same androgen-dependent disease phenotype as when mutant AR is broadly expressed, challenging the assumptions that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20689246
DOI: 10.1159/000313682
PMCID: PMC3030474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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