Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Therapeutic approaches to spinal and bulbar muscular atrophy.

Trends in pharmacological sciences - 1 Nov 2010

Ranganathan Srikanth, Fischbeck Kenneth H

Abstract excerpt

Spinal and bulbar muscular atrophy is a hereditary motor neuron disease caused by trinucleotide repeat expansion in the androgen receptor gene. The disease mechanism probably involves a toxic gain of function in the mutant protein, because other mutations that cause a loss of androgen receptor fu...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Androgen Antagonists
Share to HSP90 Heat-Shock Proteins
Share to Insulin-Like Growth Factor Binding Protein 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Chaperones

Share to Motor Neuron Disease

Share to Muscular Atrophy, Spinal

Share to Receptors, Androgen

Share to Trinucleotide Repeat Expansion

Source

Open in PubMed Open full text

Identifiers

PMID: 20863580
DOI: 10.1016/j.tips.2010.08.005
PMCID: PMC2963653

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20863580-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Therapeutic approaches to spinal and bulbar muscular atrophy.PMID 20863580Read ↗

[Molecular-targeted therapies for spinal and bulbar muscular atrophy].Semantic proximity Read ↗

Spinal and bulbar muscular atrophy: ligand-dependent pathogenesis and therapeutic perspectives.Semantic proximity Read ↗

Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy.Semantic proximity Read ↗

Silencing neuronal mutant androgen receptor in a mouse model of spinal and bulbar muscular atrophy.Semantic proximity Read ↗

Transgenic mouse models of spinal and bulbar muscular atrophy (SBMA).Semantic proximity Read ↗

Trinucleotide repeat disease. The androgen receptor in spinal and bulbar muscular atrophy.Semantic proximity Read ↗

MiR-298 Counteracts Mutant Androgen Receptor Toxicity in Spinal and Bulbar Muscular AtrophySemantic proximity Read ↗

[Development of therapeutics for spinal and bulbar muscular atrophy (SBMA)].Semantic proximity Read ↗

Neurotoxic effects of androgens in spinal and bulbar muscular atrophySemantic proximity Read ↗

Spinal and bulbar muscular atrophy: From molecular pathogenesis to pharmacological intervention targeting skeletal muscleSemantic proximity Read ↗

Clearance of the mutant androgen receptor in motoneuronal models of spinal and bulbar muscular atrophy.Semantic proximity Read ↗

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.