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Article

Genetic variants in two pathways influence serum urate levels and gout risk: a systematic pathway analysis.

Scientific reports - 1 Mar 2018

Dong Zheng, Zhou Jingru, Xu Xia, Jiang Shuai, Li Yuan, Zhao Dongbao, Yang Chengde, Ma Yanyun, Wang Yi, He Hongjun, Ji Hengdong, Zhang Juan, Yuan Ziyu, Yang Yajun, Wang Xiaofeng, Pang Yafei, Jin Li, Zou Hejian, Wang Jiucun

Abstract excerpt

The aims of this study were to identify candidate pathways associated with serum urate and to explore the genetic effect of those pathways on the risk of gout. Pathway analysis of the loci identified in genome-wide association studies (GWASs) showed that the ion transmembrane transporter activity pathway (GO: 0015075) and the secondary active transmembrane transporter activity pathway (GO: 0015291) were both...

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Identifiers

PMID: 29497127
DOI: 10.1038/s41598-018-21858-0
PMCID: PMC5832812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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