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Article

Ly6CHi Blood Monocyte/Macrophage Drive Chronic Inflammation and Impair Wound Healing in Diabetes Mellitus.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2018

Kimball Andrew, Schaller Matthew, Joshi Amrita, Davis Frank M, denDekker Aaron, Boniakowski Anna, Bermick Jennifer, Obi Andrea, Moore Bethany, Henke Peter K, Kunkel Steve L, Gallagher Katherine A

Abstract excerpt

OBJECTIVE: Wound monocyte-derived macrophage plasticity controls the initiation and resolution of inflammation that is critical for proper healing, however, in diabetes mellitus, the resolution of inflammation fails to occur. In diabetic wounds, the kinetics of blood monocyte recruitment and the mechanisms that control in vivo monocyte/macrophage differentiation remain unknown. APPROACH AND RESULTS: Here, we...

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Identifiers

PMID: 29496661
DOI: 10.1161/ATVBAHA.118.310703
PMCID: PMC5920725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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