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Article

Uncovering Sex-Related Differences in Skin Macrophage Polarization During Wound Healing in Diabetic Mice.

Frontiers in bioscience (Landmark edition) - 17 Feb 2025

Huang Coco X, Siwan Elisha, Baker Callum J, Wei Zhuoran, Shinko Diana, McGuire Helen M, Twigg Stephen M, Min Danqing

Abstract excerpt

BACKGROUND: Chronic wounds, such as diabetes-related foot ulcers, arise from delayed wound healing and create significant health and economic burdens. Macrophages regulate healing by shifting between pro- and anti-inflammatory phenotypes, known as macrophage polarization. Sex and diabetes can impair wound healing, but their influence on macrophage phenotype in skin tissue during wound healing remains unclear,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40018936
DOI: 10.31083/FBL27113

Genes

CD163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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