Article
Hypertension and increased endothelial mechanical stretch promote monocyte differentiation and activation: roles of STAT3, interleukin 6 and hydrogen peroxide.
Cardiovascular research - 1 Sept 2018
Loperena Roxana, Van Beusecum Justin P, Itani Hana A, Engel Noah, Laroumanie Fanny, Xiao Liang, Elijovich Fernando, Laffer Cheryl L, Gnecco Juan S, Noonan Jonathan, Maffia Pasquale, Jasiewicz-Honkisz Barbara, Czesnikiewicz-Guzik Marta, Mikolajczyk Tomasz, Sliwa Tomasz, Dikalov Sergey, Weyand Cornelia M, Guzik Tomasz J, Harrison David G
Abstract excerpt
Aims: Monocytes play an important role in hypertension. Circulating monocytes in humans exist as classical, intermediate, and non-classical forms. Monocyte differentiation can be influenced by the endothelium, which in turn is activated in hypertension by mechanical stretch. We sought to examine the role of increased endothelial stretch and hypertension on monocyte phenotype and function. Methods and results:...
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