Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrative functional analysis of super enhancer SNPs for coronary artery disease.

Journal of human genetics - 1 May 2018

Gong Juexiao, Qiu Chuan, Huang Dan, Zhang Yiyan, Yu Shengyong, Zeng Chunping

Abstract excerpt

Clinical research in coronary artery disease (CAD) primarily focused on genetic variants located in protein-coding regions. Recently, mutations fall within non-coding regions have been suggested to be essential to the pathogenesis of human complex disease. Super enhancer is a densely spaced cluster of transcriptional enhancers located in non-coding regions, which is critical for regulating cell-type specific gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Biology
Share to Coronary Artery Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Histones

Share to Molecular Sequence Annotation

Share to Protein Interaction Mapping

Share to Protein Interaction Maps

Share to Transcriptome

Source

Identifiers

PMID: 29491472
DOI: 10.1038/s10038-018-0422-2

Genes

CAD
MAPK1
ZMIZ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrative functional analysis of super enhancer SNPs for coronary artery disease.PMID 29491472Read ↗

Integrative analysis of super enhancer SNPs for type 2 diabetes.Semantic proximity Read ↗

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci.Semantic proximity Read ↗

Cell type-specific epigenetic regulatory circuitry of coronary artery disease lociSemantic proximity Read ↗

Integration of summary data from GWAS and eQTL studies identified novel risk genes for coronary artery disease.Semantic proximity Read ↗

Integration of Multiple-Omics Data to Analyze the Population-Specific Differences for Coronary Artery Disease.Semantic proximity Read ↗

Cell-specific chromatin landscape of human coronary artery resolves regulatory mechanisms of disease riskSemantic proximity Read ↗

Cardiovascular Disease-Associated Non-Coding Variants Disrupt GATA4-DNA Binding and Regulatory FunctionsSemantic proximity Read ↗

Network-Based Identification and Prioritization of Key Regulators of Coronary Artery Disease Loci.Semantic proximity Read ↗

Computational analysis of congenital heart disease associated SNPs: Unveiling their impact on the gene regulatory systemSemantic proximity Read ↗

What are super-enhancers?Semantic proximity Read ↗

Cell type-specific epigenetic regulatory circuitry of coronary artery disease loci.Semantic proximity Read ↗

CAD variants act through ox-LDL-induced enhancer remodelling to alter VSMC gene programmesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.