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Clinical and biological implications of mutational spectrum in acute myeloid leukemia of FAB subtypes M4 and M5.

Cancer gene therapy - 1 May 2018

Cheng Zhiheng, Hu Kai, Tian Lei, Dai Yifeng, Pang Yifan, Cui Wei, Zhao Hongmian, Qin Tong, Han Yu, Hu Ning, Chen Li, Wang Chao, Zhang Yijie, Wu Depei, Ke Xiaoyan, Shi Jinlong, Fu Lin

Abstract excerpt

The mutational spectrum and molecular characteristics of acute myelomonocytic lineage leukemia, namely acute myeloid leukemia (AML) French-American-British (FAB) subtypes M4 and M5, are largely unknown. In order to explore the mutational spectrum and prognostic factors of FAB-M4 and -M5, next-generation sequencing (NGS) was performed to screen for mutated genes and fusion genes relevant to the pathogenesis of...

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Identifiers

PMID: 29491461
DOI: 10.1038/s41417-018-0013-6

Genes

EFS
FLT3
MYH11
NPM1
NRAS
RUNX1
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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