Article
Driver mutations occur frequently in metastases of well-differentiated small intestine neuroendocrine tumours.
Histopathology - 1 Mar 2021
Samsom Kris G, Levy Sonja, van Veenendaal Linde M, Roepman Paul, Kodach Liudmila L, Steeghs Neeltje, Valk Gerlof D, Wouter Dercksen M, Kuhlmann Koert F D, Verbeek Wieke H M, Meijer Gerrit A, Tesselaar Margot E T, van den Berg José G
Abstract excerpt
AIMS: To investigate the clinicopathological significance of driver mutations in metastatic well-differentiated small intestine neuroendocrine tumours (SI-NETs). METHODS AND RESULTS: Whole genome sequencing (WGS) of 35 metastatic SI-NETs and next-generation sequencing (NGS) of eight metastatic SI-NETs were performed. Biopsies were obtained between 2015 and 2019. Tumours were classified according to the 2019 World...
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