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Article

Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity.

Nature communications - 28 Feb 2018

Steinhardt James J, Guenaga Javier, Turner Hannah L, McKee Krisha, Louder Mark K, O'Dell Sijy, Chiang Chi-I, Lei Lin, Galkin Andrey, Andrianov Alexander K, A Doria-Rose Nicole, Bailer Robert T, Ward Andrew B, Mascola John R, Li Yuxing

Abstract excerpt

HIV-1 broadly neutralizing antibodies (bNAbs) are being explored as passively administered therapeutic and preventative agents. However, the extensively diversified HIV-1 envelope glycoproteins (Env) rapidly acquire mutations to evade individual bNAbs in monotherapy regimens. The use of a "single" agent to simultaneously target distinct Env epitopes is desirable to overcome viral diversity. Here, we report the...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to env Gene Products, Human Immunodeficiency Virus

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Source

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Identifiers

PMID: 29491415
DOI: 10.1038/s41467-018-03335-4
PMCID: PMC5830440

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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