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Article

Candida albicans possesses Sap7 as a pepstatin A-insensitive secreted aspartic protease.

PloS one - 1 Jan 2012

Aoki Wataru, Kitahara Nao, Miura Natsuko, Morisaka Hironobu, Yamamoto Yoshihiro, Kuroda Kouichi, Ueda Mitsuyoshi

Abstract excerpt

BACKGROUND: Candida albicans, a commensal organism, is a part of the normal flora of healthy individuals. However, once the host immunity is compromised, C. albicans opportunistically causes recurrent superficial or fatal systemic candidiasis. Secreted aspartic proteases (Sap), encoded by 10 types of SAP genes, have been suggested to contribute to various virulence processes. Thus, it is important to elucidate...

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Identifiers

PMID: 22384266
DOI: 10.1371/journal.pone.0032513
PMCID: PMC3287985

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