Article
Two-step evolution of the hepatitis B drug-resistant mutations in a patient who developed primary entecavir resistance.
Liver international : official journal of the International Association for the Study of the Liver - 1 Apr 2013
Lee Guan-Huei, Inoue Masafumi, Toh Jimmy K-P, Chong Roxanne H-H, Aung Myat-Oo, Koay Evelyn S-C, Lim Seng-Gee
Abstract excerpt
AIM: Few cases of primary entecavir resistance in chronic hepatitis B patients have been reported to date. The serial profiling of the HBV polymerase gene mutations from a treatment-naive patient who developed drug resistance after 32 months of entecavir therapy is presented here. DESIGN: Serum samples were collected at multiple time points from before the start of therapy to virological and biochemical...
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