Article
The p53-inducible CLDN7 regulates colorectal tumorigenesis and has prognostic significance.
Neoplasia (New York, N.Y.) - 1 Nov 2020
Hou Yichao, Hou Lidan, Liang Yu, Zhang Qingwei, Hong Xialu, Wang Yu, Huang Xin, Zhong Ting, Pang Wenjing, Xu Ci, Zhu Liming, Li Lei, Fang Jingyuan, Meng Xiangjun
Abstract excerpt
Most colorectal cancer (CRC) are characterized by allele loss of the genes located on the short arm of chromosome 17 (17p13.1), including the tumor suppressor p53 gene. Although important, p53 is not the only driver of chromosome 17p loss. In this study, we explored the biological and prognostic significance of genes around p53 on 17p13.1 in CRC. The Cancer Genome Atlas (TCGA) were used to identify differentially...
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