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Article

Wdpcp promotes epicardial EMT and epicardium-derived cell migration to facilitate coronary artery remodeling.

Science signaling - 27 Feb 2018

Liu Xiangyang, Wang Ye, Liu Feng, Zhang Min, Song Hejie, Zhou Bin, Lo Cecilia W, Tong Shilu, Hu Zhenlei, Zhang Zhen

Abstract excerpt

During coronary vasculature development, endothelial cells enclose the embryonic heart to form the primitive coronary plexus. This structure is remodeled upon recruitment of epicardial cells that may undergo epithelial-mesenchymal transition (EMT) to enable migration and that give rise to smooth muscle cells. In mice expressing a loss-of-function mutant form of Wdpcp, a gene involved in ciliogenesis, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29487191
DOI: 10.1126/scisignal.aah5770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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