Article
Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System.
Structure (London, England : 1993) - 6 Mar 2018
Bunney Tom D, Inglis Alison J, Sanfelice Domenico, Farrell Brendan, Kerr Christopher J, Thompson Gary S, Masson Glenn R, Thiyagarajan Nethaji, Svergun Dmitri I, Williams Roger L, Breeze Alexander L, Katan Matilda
Abstract excerpt
Receptor tyrosine kinase FGFR3 is involved in many signaling networks and is frequently mutated in developmental disorders and cancer. The Hsp90/Cdc37 chaperone system is essential for function of normal and neoplastic cells. Here we uncover the mechanistic inter-relationships between these proteins by combining approaches including NMR, HDX-MS, and SAXS. We show that several disease-linked mutations convert...
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