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Article

Genetic variants of methionine metabolism and X-ALD phenotype generation: results of a new study sample.

Journal of neurology - 1 Aug 2009

Semmler Alexander, Bao Xinhua, Cao Guangna, Köhler Wolfgang, Weller Michael, Aubourg Patrick, Linnebank Michael

Abstract excerpt

X-linked adrenoleukodystrophy (X-ALD) is the most common inherited leukodystrophy. Nevertheless, no genotype-phenotype correlation has been established so far. Unidentified modifier genes or other cofactors are suspected to modulate phenotype and prognosis. We recently described polymorphisms of methionine metabolism as possible disease modifiers in X-ALD. To retest these findings, we analyzed 172 new DNA samples...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19353223
DOI: 10.1007/s00415-009-5114-6

Genes

AMN
CBS
DHFR
MTHFR
MTR
MTRR
RFC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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