Article
Characterization of Postinfusion Phenotypic Differences in Fresh Versus Cryopreserved TCR Engineered Adoptive Cell Therapy Products.
Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jun 2018
Nowicki Theodore S, Escuin-Ordinas Helena, Avramis Earl, Chmielowski Bartosz, Chodon Thinle, Berent-Maoz Beata, Wang Xiaoyan, Kaplan-Lefko Paula, Yang Lili, Baltimore David, Economou James S, Ribas Antoni, Comin-Anduix Begoña
Abstract excerpt
Adoptive cell therapy (ACT) consisting of genetically engineered T cells expressing tumor antigen-specific T-cell receptors displays robust initial antitumor activity, followed by loss of T-cell activity/persistence and frequent disease relapse. We characterized baseline and longitudinal T-cell phenotype variations resulting from different manufacturing and administration protocols in patients who received ACT....
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