Article

CD4 <sup>+</sup> tumor-infiltrating lymphocytes secreting T cell-engagers induce regression of autologous patient-derived non-small cell lung cancer xenografts

2024-06-01

Abstract excerpt

<h4>ABSTRACT</h4> Adoptive transfer of tumor-infiltrating lymphocytes (TIL) has shown remarkable results in melanoma, but only modest clinical benefit in other cancers, even after TIL have been genetically modified to improve their tumor homing, cytotoxic potential or overcoming cell exhaustion. The required ex vivo TIL expansion process may induce changes in the T cell clonal composition, which could likely com...

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Literature Corpus work: c792b63a-e4eb-541b-b118-576e55e710ae
DOI: 10.1101/2024.05.27.596077

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