Article
Detection of a rare CYP3A4 variant in a transplant patient characterized by a tacrolimus poor metabolizer phenotype.
Pharmacogenomics - 1 Mar 2018
Lloberas Nuria, Hesselink Dennis A, van Schaik Ron Hn, Grinyò Josep M, Colom Helena, Gelder Teun van, Elens Laure
Abstract excerpt
A validated CYP3A genotype classification system allows clustering patients into poor, intermediate and extensive metabolizer phenotypes. However, substantial overlap exists between the clusters. A rare CYP3A4 allele, named CYP3A4*20 (rs67666821), has been specifically described in the Spanish population. The authors investigated the relevance of CYP3A4*20 testing to see if the above-mentioned metabolic CYP3A...
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