Article
Influence of donor liver CYP3A4*20 loss-of-function genotype on tacrolimus pharmacokinetics in transplanted patients.
Pharmacogenetics and genomics - 1 Feb 2018
Gómez-Bravo Miguel A, Apellaniz-Ruiz María, Salcedo Magdalena, Fondevila Constantino, Suarez Francisco, Castellote José, Rufian Sebastián, Pons José A, Bilbao Itxarone, Alamo José M, Millán Olga, Brunet Mercè, Rodríguez-Antona Cristina
Abstract excerpt
OBJECTIVE: Cytochrome P450 3A4 (CYP3A4) metabolizes about half of all drugs on the market; however, the impact of CYP3A4 loss-of-function variants on drug exposures remains poorly characterized. Here, we report the effect of the CYP3A4*20 frameshift allele in two Spanish liver transplant patients treated with tacrolimus. PATIENTS AND METHODS: A series of 90 transplanted patients (with DNA available for 89 of the...
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