Evaluation of the Leishmania Inositol Phosphorylceramide Synthase as a Drug Target Using a Chemical and Genetic Approach

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide The lack of effective vaccines and the development of resistance to the current treatments highlight the urgent need for new anti-leishmanials. Sphingolipid metabolism has been proposed as a promising source of Leishmania -specific targets as these lipids are key structural components of the eukaryotic plasma membrane and are involved in distinct cellular events....

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