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Article

Effect of genetic variation in UGT1A and ABCB1 on moxifloxacin pharmacokinetics in South African patients with tuberculosis.

Pharmacogenomics - 1 Jan 2018

Naidoo Anushka, Ramsuran Veron, Chirehwa Maxwell, Denti Paolo, McIlleron Helen, Naidoo Kogieleum, Yende-Zuma Nonhlanhla, Singh Ravesh, Ngcapu Sinaye, Chaudhry Mamoonah, Pepper Michael S, Padayatchi Nesri

Abstract excerpt

AIM: We assessed the effect of genetic variability in UGT1A and ABCB1 genes on moxifloxacin pharmacokinetics. METHODS: Genotypes for selected UGT1A and ABCB1 SNPs were determined using a TaqMan® Genotyping OpenArray™ and high-resolution melt analysis for rs8175347. A nonlinear mixed-effects model was used to describe moxifloxacin pharmacokinetics. RESULTS: Genotypes of UGT1A SNPs, rs8175347 and rs3755319 (20.6%...

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Share to Anti-Bacterial Agents
Share to ATP Binding Cassette Transporter, Subfamily B
Share to Fluoroquinolones
Share to Genotype
Share to Glucuronosyltransferase
Share to Moxifloxacin
Share to Polymorphism, Single Nucleotide
Share to Tuberculosis

Source

Open in PubMed Open full text

Identifiers

PMID: 29210323
DOI: 10.2217/pgs-2017-0144
PMCID: PMC5753622

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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