Article
Population pharmacokinetics and pharmacogenetics of apatinib in adult cancer patients.
British journal of clinical pharmacology - 1 Jun 2023
Yang Xin-Mei, Ye Pan-Pan, Liu Xiao-Lin, Guo Zi-Xuan, Kan Min, Li Qian, Song Lin-Lin, Liu Hong-Ying, Chen Ke-Guang, Shi Jin-Yi, Zhang Ye-Hui, Li Ya, Zhao Fu-Rong, van den Anker John, Li Yan, Zhao Wei
Abstract excerpt
AIMS: Apatinib is widely used in Chinese cancer patients. As the in vivo drug disposition of apatinib has large individual differences, adverse events are prone to occur. Cytochrome P450 (CYP)3A5 and cancer types maybe the main factors affecting this individual differences. The objective of our study was to establish a population pharmacokinetics (PK) model of apatinib in adult cancer patients, and to explore...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.