A common variant alters SCN5A-miR-24 interaction and associates with heart failure mortality.

doi:10.1172/JCI95710

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Article

A common variant alters SCN5A-miR-24 interaction and associates with heart failure mortality.

The Journal of clinical investigation - 1 Mar 2018

Zhang Xiaoming, Yoon Jin-Young, Morley Michael, McLendon Jared M, Mapuskar Kranti A, Gutmann Rebecca, Mehdi Haider, Bloom Heather L, Dudley Samuel C, Ellinor Patrick T, Shalaby Alaa A, Weiss Raul, Tang W H Wilson, Moravec Christine S, Singh Madhurmeet, Taylor Anne L, Yancy Clyde W, Feldman Arthur M, McNamara Dennis M, Irani Kaikobad, Spitz Douglas R, Breheny Patrick, Margulies Kenneth B, London Barry, Boudreau Ryan L

Abstract excerpt

SCN5A encodes the voltage-gated Na+ channel NaV1.5 that is responsible for depolarization of the cardiac action potential and rapid intercellular conduction. Mutations disrupting the SCN5A coding sequence cause inherited arrhythmias and cardiomyopathy, and single-nucleotide polymorphisms (SNPs) linked to SCN5A splicing, localization, and function associate with heart failure-related sudden cardiac death. However,...

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PMID: 29457789
DOI: 10.1172/JCI95710
PMCID: PMC5824852

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