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Article

Gene-environment interaction between SCN5A-1103Y and hypokalemia influences QT interval prolongation in African Americans: the Jackson Heart Study.

American heart journal - 1 Jan 2014

Akylbekova Ermeg L, Payne John P, Newton-Cheh Christopher, May Warren L, Fox Ervin R, Wilson James G, Sarpong Daniel F, Taylor Herman A, Maher Joseph F

Abstract excerpt

BACKGROUND: African-American ancestry, hypokalemia, and QT interval prolongation on the electrocardiogram are all risk factors for sudden cardiac death (SCD), but their interactions remain to be characterized. SCN5A-1103Y is a common missense variant, of African ancestry, of the cardiac sodium channel gene. SCN5A-1103Y is known to interact with QT-prolonging factors to promote ventricular arrhythmias in persons...

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Source

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Identifiers

PMID: 24332150
DOI: 10.1016/j.ahj.2013.10.009
PMCID: PMC3884587

Genes

SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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