Article
CSF lamp2 concentrations are decreased in female Parkinson's disease patients with LRRK2 mutations.
Brain research - 15 Mar 2018
Klaver Andrea C, Coffey Mary P, Aasly Jan O, Loeffler David A
Abstract excerpt
Lysosome-associated membrane glycoprotein 2 (lamp2) plays critical roles in chaperone-mediated autophagy (CMA) and macroautophagy. Its isoform lamp2a is decreased in Parkinson's disease (PD) substantia nigra. Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most known common cause of late-onset PD; although LRRK2 is thought to regulate macroautophagy, the influence of LRRK2 mutations on lamp2...
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