Article
CFTR mutation enhances Dishevelled degradation and results in impairment of Wnt-dependent hematopoiesis.
Cell death & disease - 15 Feb 2018
Sun Huaqin, Wang Yan, Zhang Jieting, Chen Yan, Liu Yanyan, Lin Ziyuan, Liu Mingfeng, Sheng Kai, Liao Huijuan, Tsang Kam Sze, Zhang Xiaohu, Jiang Xiaohua, Xu Wenming, Mao Meng, Chan Hsiao Chang
Abstract excerpt
Mutations of cystic fibrosis transmembrane conductance regulator (CFTR) cause cystic fibrosis (CF) with a multitude of clinical manifestations. Some CF patients develop clinically significant anemia, suggesting that CFTR may regulate hematopoiesis. Here, we report that cftr mutant zebrafish model exhibits primitive and definitive hematopoietic defects with impaired Wnt signaling. Cftr is found to interact, via...
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