Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CFTR regulates embryonic T lymphopoiesis via Wnt signaling in zebrafish.

Immunology letters - 1 Jun 2021

Lin Ziyuan, Luo Min, Zhou Bin, Liu Yanyan, Sun Huaqin

Abstract excerpt

The number and function of T cells are abnormal as observed in cystic fibrosis (CF) patients and CF mouse models, and our previous work shows that the CFTR mutant leads to deficiency of primitive and definitive hematopoietic in zebrafish. However, the functions and underlying mechanisms of CFTR in T cell development during early embryogenesis have not been explored. Here, we report that the genetic ablation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Biology
Share to Cystic Fibrosis Transmembrane Conductance Regulator

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Ontology

Share to Hematopoietic Stem Cells

Share to Lymphopoiesis

Share to T-Lymphocytes

Share to Wnt Signaling Pathway

Share to Zebrafish

Source

Identifiers

PMID: 33951474
DOI: 10.1016/j.imlet.2021.04.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CFTR regulates embryonic T lymphopoiesis via Wnt signaling in zebrafish.PMID 33951474Read ↗

The zebrafish: a new model of T-cell and thymic development.Semantic proximity Read ↗

Cystic fibrosis transmembrane conductance regulator (CFTR) regulates embryonic organizer formation during zebrafish early embryogenesis.Semantic proximity Read ↗

CFTR mutation enhances Dishevelled degradation and results in impairment of Wnt-dependent hematopoiesis.Semantic proximity Read ↗

CFTR deficiency causes cardiac dysplasia during zebrafish embryogenesis and is associated with dilated cardiomyopathy.Semantic proximity Read ↗

Deletion of cftr Leads to an Excessive Neutrophilic Response and Defective Tissue Repair in a Zebrafish Model of Sterile InflammationSemantic proximity Read ↗

Deletion of <i>cftr</i> leads to an excessive neutrophilic response and defective tissue repair in a zebrafish model of sterile inflammationSemantic proximity Read ↗

CFTR deficiency causes cardiac dysplasia during zebrafish embryogenesis and is associated with dilated cardiomyopathySemantic proximity Read ↗

CFTR deficiency causes cardiac dysplasia during zebrafish embryogenesis and is associated with dilated cardiomyopathySemantic proximity Read ↗

Chd7 Is Critical for Early T-Cell Development and Thymus Organogenesis in Zebrafish.Semantic proximity Read ↗

Loss of cftr function leads to pancreatic destruction in larval zebrafishSemantic proximity Read ↗

Bone Cells Differentiation: How CFTR Mutations May Rule the Game of Stem Cells Commitment?Semantic proximity Read ↗

Specific Resistance to Pseudomonas aeruginosa Infection in Zebrafish Is Mediated by the Cystic Fibrosis Transmembrane Conductance RegulatorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.