Article
CFTR deficiency causes cardiac dysplasia during zebrafish embryogenesis and is associated with dilated cardiomyopathy.
Mechanisms of development - 1 Sept 2020
Liu Yanyan, Lin Ziyuan, Liu Mingfeng, Liao Huijuan, Chen Yan, Zhang Xiaohu, Chan Hsiao Chang, Zhou Bin, Rao Li, Sun Huaqin
Abstract excerpt
Mutations in the CFTR gene cause cystic fibrosis (CF) with myocardial dysfunction. However, it remains unknown whether CF-related heart disease is a secondary effect of pulmonary disease, or an intrinsic primary defect in the heart. Here, we used zebrafish, which lack lung tissue, to investigate the role of CFTR in cardiogenesis. Our findings demonstrated that the loss of CFTR impairs cardiac development from the...
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