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Article

Defective CFTR leads to aberrant β-catenin activation and kidney fibrosis.

Scientific reports - 12 Jul 2017

Zhang Jie Ting, Wang Yan, Chen Jun Jiang, Zhang Xiao Hu, Dong Jian Da, Tsang Lai Ling, Huang Xiao Ru, Cai Zhiming, Lan Hui Yao, Jiang Xiao Hua, Chan Hsiao Chang

Abstract excerpt

Cystic fibrosis transmembrane conductance regulator (CFTR), known as a cAMP-activated Cl- channel, is widely expressed at the apical membrane of epithelial cells in a wide variety of tissues. Of note, despite the abundant expression of CFTR in mammalian kidney, the role of CFTR in kidney disease development is unclear. Here, we report that CFTR expression is downregulated in the UUO (unilateral ureteral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28701694
DOI: 10.1038/s41598-017-05435-5
PMCID: PMC5507915

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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