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Article

PDZ Structure and Implication in Selective Drug Design against Cystic Fibrosis.

Current drug targets - 1 Jan 2015

Holcomb Joshua, Spellmon Nicholas, Trescott Laura, Sun Fei, Li Chunying, Yang Zhe

Abstract excerpt

PDZ domains play an essential role in a number of cellular processes by facilitating protein scaffolding and assembly of protein complexes. These domains consist of 80 to 90 amino acids and are found to recognize short C-terminal sequences of target proteins. Protein complex formation between PDZ target molecules can lead to a number of signaling and regulatory cascades that may either promote or inhibit the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25523900
DOI: 10.2174/1389450116666141219120125

Genes

CFTR
NHERF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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